3. 八臂迷宮（Radial Arm Maze）
Subjects are placed in the center of an eight-arm radial maze. Four randomly chosen arms are baited with food pellets in opaque containers. The subject is given the opportunity to visit all the arms and collect all the available food pellets. After a rentention delay, the subject is returned to the maze. In win-stay conditions, the same four arms are baited, and the number of correct choices the subject makes in collecting the pellets is recorded. In win-shift conditions, the four arms NOT baited in the earlier trial are now baited, and the number of correct arm choices is recorded. Each day, a new set of four arms is chosen randomly.
八臂迷宮用來檢測藥物或大腦受損狀態下學習和記憶方面的表現，它由八個完全相同的臂組成，這些臂從一個中央平臺放射出來，所以又被稱為放射迷宮每個臂盡頭有食物提供裝置，根據分析動物取食的策略即進入每臂的次數、時間、正確次數、錯誤次數、路線等參數可以反映出實驗動物的空間記憶能力。相對而言，八臂迷宮操作簡便、可行，而且能區分短期的工作記憶和長期的參考記憶，現已被廣泛用于學習記憶功能評價。
4. 自主活動、曠場實驗（Open Field）
The subject is placed in the activity chamber for a specified time period. Activity levels and movement in three dimensions are recorded by the activity system and can be analyzed for evidence of hyperactiviy, hypoactivity, anxiety, explorative behaviors, and stereotyped rotation.
自發活動曠場曠場分析系統是觀察研究實驗動物神經精神變化、進入開闊環境后的各種行為，例如動物對新開闊環境的恐懼而主要在周邊區域活動，在中央區域活動較少，但動物的探究特性又促使其產生在中央區域活動的動機，也可觀察由此而產生的焦慮心理。中樞興奮藥物可以明顯增加自主的活動而減少探究行為，一定劑量的抗精神病藥物可以減少探究行為而不影響自主活動。
5. 高架十字迷宮（Elevated Plus Maze）
高架十字迷宮是利用動物對新異環境的探究特性和對高懸敞開臂的恐懼形成矛盾沖突行為來考察動物的焦慮狀態。高架十字迷宮具有一對開臂和一對閉臂，高架十字迷宮距離地面較高，相當于人站在峭壁上，使實驗對象產生恐懼和不安心理。高架十字迷宮被廣泛應用于新藥開發、藥理學、毒理學、預防醫學、神經生物學、動物心理學等多個學科的科學-研究和計算機輔助教學等領域，是醫學院校與科研機構開展焦慮抑郁研究的經典實驗。
The animal is placed in the center of the apparatus and observed for a set time. Measurements compare the include total time spent in the open and closed arms (and central platform) as well as entries into the open and closed arms.
6. 黑白箱實驗（light dark box）
The subject is placed in the dark portion of the box for a set period of acclimation time. At the end of this period, a door separating the two compartments is opened. The amount of time that the subject takes to emerge fully from the enclosed area into the open area is measured.
7. 社交行為實驗（social interaction）
The subject is habituated to the test chamber and allowed to freely explore for a set time. A novel animal is placed in one of the two enclosures, and the percentage of time the mouse spends in the section with the novel animal is compared to the time spent in the section with the empty enclosure. In a later session, the time spent with the same animal might be compared to time spent with a newer, more novel animal.
8. 條件性位置偏愛（Conditioned Place Preference）
條件性位置偏愛實驗（CPP）實驗是目前評價藥物精神依賴性的經典實驗模型。該實驗將實驗動物（大鼠、小鼠）置于條件性位置偏愛箱的白色觀察區，并給予精神依賴性藥物然后觀察實驗動物在條件性位置偏愛箱的黑色區和白色區的活動情況，白色區、黑色區以及其中的灰色區之間有小門可供動物自由穿梭。動物每次處于給藥區就會在藥物獎賞性效應的作用下對黑色和白色區域產生位置上的偏好，其程度與藥物的精神依賴性相關。
A drug is injected and the subject is introduced to distinctive environment A. This procedure is repeated for several trials. During these conditioning trials the animal develops an association between the subjective state produced by the drug (often drugs that produce mood elevation or euphoria in humans) and the contextual cues present while the drug is active. To test the conditioning, the animal is placed in an apparatus with drug-related cues in one compartment and neutral cues in the other. nbsp; If conditioning occurred, the animal will move toward the compartment containing the drug-related cues.
In a Conditioned Place Preference experiment, subjects are returned to an apparatus were they can freely move between a compartment in which they were conditioned with drug-related cues, and a compartment with neutral cues. If the conditioning was successful for positive, reinforcing drug states, they should spend more time in the compartment with drug-related cues。
In a Conditioned Place Aversion experiment, subjects are returned to an apparatus were they can freely move between a compartment in which they were conditioned with an aversive stimulus, such as a shock; and a compartment with neutral cues. If the aversive conditioning was successful, they should spend more time in the compartment with neutral cues.
